Data from the 2005 Monitoring the Future survey were used to examine relationships between school-related factors and high school seniors' lifetime methamphetamine use. The study applied logistic regression techniques to evaluate effects of social bonding variables and social learning variables on likelihood of lifetime methamphetamine use. The results confirmed that likelihood of such use was higher when social bonding factors were weak and social learning factors were strong. Results also showed the social bonds' impact to be mediated by social learning factors. Policy implications are discussed briefly.