Bisphosphonate Prodrugs
Copyright policy )Bisphosphonate Prodrugs
Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH. Using the prodrug approach, oral absorption can be increased by masking one or more ionizable groups (clodronate, etidronate), or using a targeting carrier system (alendronate, pamitronate).
- Kuopio University Hospital Finland
Diphosphonates, Hydrolysis, Administration, Oral, Biological Availability, Etidronic Acid, Hydrogen-Ion Concentration, Structure-Activity Relationship, Drug Delivery Systems, Intestinal Absorption, Animals, Humans, Prodrugs, Tissue Distribution, Clodronic Acid
Diphosphonates, Hydrolysis, Administration, Oral, Biological Availability, Etidronic Acid, Hydrogen-Ion Concentration, Structure-Activity Relationship, Drug Delivery Systems, Intestinal Absorption, Animals, Humans, Prodrugs, Tissue Distribution, Clodronic Acid
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