Moisture problems are prevalent all over North America, almost independent of climate. They are viewed as one of the single largest factors limiting the useful service life of a building. Elevated levels of moisture in buildings also can lead to serious health effects for occupants. Until recently, very little consensus on moisture control existed in the building community. The information available was typically incomplete, contradictory, usually limited to specific regions, and in many cases misleading. A need to develop a document which presented the issues relating to moisture from a building science or ``systems`` approach existed. This handbook attempts to fill that need and illustrates that energy-efficient, tight envelope design is clearly part of the solution to healthy buildings when interior relative humidity, temperature, and pressure are controlled simultaneously. The first three chapters of the handbook present the basic principles of moisture problems and solutions in buildings. Chapter 1 -- Mold, Mildew, and Condensation, examines surface moisture problems. Chapter 2 -- Moisture Movement, examines how building assemblies get wet from both the exterior and interior. Chapter 3 -- Wetting and Drying of Building Assemblies, introduces the concepts of acceptable performance, moisture balance, and the redistribution of moisture within building assemblies. Chapters 4 through 6 apply the concepts outlined in the previous chapters and present specific moisture control practices for three basic US climate zones. The advantages and disadvantages of several wall, foundation, and roof assemblies are discussed for each climate zone.