The goals of this research are the experimental testing of fundamental theories of physics such as grand unification and the exploration of cosmic phenomena through the techniques of particle physics. We are working on the MACRO experiment, which employs a large area underground detector to search for grand unification magnetic monopoles and dark matter candidates and to study cosmic ray muons as well as low and high energy neutrinos: the {nu}IMB project, which seeks to refurbish and upgrade the IMB water Cerenkov detector to perform an improved proton decay search together with a long baseline reactor neutrino oscillation experiment using a kiloton liquid scintillator (the Perry experiment); and development of technology for improved liquid scintillators and for very low background materials in support of the MACRO and Perry experiments and for new solar neutrino experiments. 21 refs., 19 figs., 6 tabs.