Nine diverse genotypes of cherry tomatoes (Solanum lycopersicum var. cerasiforme) were crossed to produce thirty six hybrids. All hybrids and their parents along with the commercial hybrid Katalina-522 were tested during winter seasons of 2014/15 and 2015/16 for their mean performance and heterosis based on high parent under greenhouse conditions at Kaha Vegetable Research Farm, Kaliobia Governorate, Horticulture Research Institute, Agriculture Research Center, Egypt. The performances of the produced F1 hybrids indicated that there are some crosses showed significant high values for reasonable characters compared with the commercial hybrid. The crosses Ch 3 × Ch 16, Ch 16 × Ch 22, Ch 18 × Ch 22 and Ch 22 × Ch 25 exhibited significant highest values of yield/plant. Also, some F1 hybrids showed significant heterosis based on high parent for some evaluated traits, viz., total yield/plant, fruit firmness, fruit flesh thickness,fruit TSS fruit and ascorbic acid content.