Brucellosis is a globally distributed zoonotic disease that causes serious problems in developing countries such as Ethiopia. Brucella abortus is the primary cause of brucellosis in cattle, and Brucella melitensis and Brucella suis also occasionally cause Brucella infection in cattle. Abortion and the retained fetal membrane are typical signs in females, whereas orchitis and bursitis are the known signs in male cattle. Brucellosis is typically transmitted to healthy cattle by direct or indirect contact with diseased cattle or their discharges. Humans can acquire brucellosis through the consumption of unpasteurized milk or milk products, and through contact with diseased cattle or their discharges. The occurrence of bovine brucellosis is affected by different factors related to the management system, host, and environmental factors. In Ethiopia, the occurrence of brucellosis is high in pastoral and mixed cattle management systems, wherever humans live closely with cattle and so have a higher probability of picking up the Brucella organism. The most suitable technique in the management of Brucella infection is the vaccination of young female cattle. Brucella abortus can also be eradicated by the isolation of diseased cattle, administration of immunizing agents, and test-and-slaughter methods. Therefore, it is important to implement applicable management techniques and to increase public awareness about the transmission of brucellosis, and further research should be conducted on brucellosis in high-risk groups.