PTPIP51 Crosslinks the NFκB Signaling and the MAPK Pathway in SKBR3 Cells

descriptionPublicationkeyboard_double_arrow_right Article 04 Mar 2020Embargo end date: 24 Aug 2022 Germany English Publisher:Informa UK LimitedJournal:Future Science OA, volume 6 (eissn: 2056-5623,

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Authors: Dietel, Eric; Brobeil, Alexander; Tag, Claudia; Gattenlöhner, Stefan; Wimmer, Monika; Justus Liebig University Giessen;

APC: 1,558.5 EUR

doi: 10.2144/fsoa-2019-0136 , 10.22029/jlupub-6371

pmid: 32518680

pmc: PMC7273389

PTPIP51 Crosslinks the NFκB Signaling and the MAPK Pathway in SKBR3 Cells

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Abstract

PTPIP51 interacts with NFκB signaling at the RelA and IκB level. NFκB signaling is linked to the initiation, progression and metastasis of breast cancer. Her2-amplified breast cancer cells frequently display activation of the NFκB signaling. We aimed to clarify the effects of NFκB inhibition on the NFκB- and MAPK-related interactome of PTPIP51 and cell viability in HaCat cells and SKBR3 cells.IKK-16 selectively reduced cell viability in SKBR3 cells. PDTC induced a formation of the Raf1/14-3-3/PTPIP51 complex in SKBR3 cells, indicating a shift of PTPIP51 into MAPK signaling.IKK-16 selectively inhibits cell viability of SKBR3 cells. In addition, PTPIP51 might serve as the mediator between NFκB signaling and the MAPK pathway in SKBR3.

Country

Germany

Related Organizations

MEDIZINISCHE UNIVERSITAT GRAZ
Austria
Pathologisches Institut
Germany
Johannes Kepler University of Linz
Austria
Justus Liebig University Giessen
Germany

Keywords

Medicine (General), ddc:610, R, protein–protein interactions, breast cancer, Her2, R5-920, Medicine, PDTC, IKK-16, NFκB, Research Article

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