This thesis presents Nothing Matters – A Theory of Everything (NMTOE), a unified ontological framework bridging the domains of metaphysics, physics, and emergent complexity. Starting from the Plane of Nothing (PoN) and the Non-Spatial Potential (NSP), the work develops a rigorous pathway from primordial energy (PE) and Life Energy (LE) to the emergent structures of the Emerged Universe (EU) and intelligent systems. Central to this framework are novel constructs such as Popies, Popation, and the Intensified Density Critical Emergent Ecosystem (IDCEE), which formalize the mechanisms of emergence, coherence, and self-organization across scales. The thesis introduces the Principle of Dimensional Differentiation at Thresholds (PDDT) and the Axiom of Differentiated Reality (ADR) as foundational principles, demonstrating that differentiation is both necessary and sufficient for the existence of Reality. By integrating cosmic intelligence (CI), human intelligence (HI), and supra-intelligence (SI) within a unified ecosystemic context, NMTOE establishes a scalable model for the evolution of complexity from the primordial substrate to conscious life. The work reconciles philosophical insight with empirical physics, exploring implications for cosmology, quantum mechanics, emergent phenomena, and the origin of life, while providing predictive and testable avenues through the Actuality Gateway (AG) and Intrinsic Molding Factor (IMF) frameworks. Ultimately, NMTOE advances a coherent theory that situates the universe, life, and intelligence within a single ontological continuum, offering both explanatory depth and conceptual clarity.