Snow cover is an important part of the Earth’s surface and its changes affect local and even global climates due to the high albedo and heat insulation. However, it is difficult to directly compare the results of previous studies on changes in snow cover in the Northern Hemisphere mainland (NH) due to the use of different datasets, research methods, or study periods, and a lack comparison in terms of the differences and similarities at high latitudes and high altitudes. By using snow depth datasets, we analyzed the spatio-temporal distributions and variations in snow depth (SD) and snow phenology (SP) in the NH and nine typical areas. This study revealed that SD in the NH generally decreased significantly (p < 0.01) from 1988 to 2018, with a rate of −0.55 cm/decade. Changes in SD were insignificant at high altitudes, but significant decreases were found at high latitudes. With regard to SP, the snow cover onset day (SCOD) advanced in 31.57% of the NH and was delayed in 21.10% of the NH. In typical areas such as the Rocky Mountains, the West Siberian Plain, and the Central Siberian Plateau, the SCOD presented significant advancing trends, while a significant delay was the trend observed in the Eastern European Plain. The snow cover end day (SCED) advanced in 37.29% of the NH and was delayed in 14.77% of the NH. Negative SCED trends were found in most typical areas. The snow cover duration (SCD) and snow season length (SSL) showed significant positive trends in the Rocky Mountains, while significant negative trends were found in the Qinghai–Tibet Plateau. The results of this comprehensive comparison showed that most typical areas were characterized by decreased SD, advanced SCOD and SCED, and insignificantly increasing SCD and SSL trends. The SCD and SSL values were similar at high latitudes, while the SSL value was larger than the SCD value at high altitudes. The SD exhibited similar interannual fluctuation characteristics as the SCD and SSL in each typical area. The SCD and SSL increased (decreased) with advanced (delayed) SCODs.