OME3-5 is regarded as option to decarbonize heavy duty transportation in the future, however cost and resulting market potential remain unclear. This analysis applies recently published TEA and LCA Guidelines for CCU on OME3-5 e-fuels produced from flue gas, water, electricity and steam in the anhydrous trioxane and OME1 pathway. The study shows that under current assumptions and at the current state of development, OME3-5 e-fuels result in significantly higher cost of goods manufactured per GJ than diesel fuel at gas stations in Germany and less than 38.4% of electricity can be stored in the e-fuel based on lower heating value. The strongest economic barriers are electricity consumption and electrolyzer stack cost, rather than OME conversion cost. However, even drastic reduction of electricity or electrolyzer prices would not make the OME3-5 anhydrous pathway competitive under current conditions and significant further reaction and process improvements are necessary.