This paper explores the issue area of global public-private partnerships (PPPs) against intellectual property (IP) crimes. It is based on preliminary findings from a PhD re-search project that included interviews with more than 30 participants of such PPPs from different countries around the world. Key factors that influence the formation, maintenance, termination, and reform of such partnerships are identified by comparing more and less successful PPPs over a period of time. First, the paper introduces the topic of IP crime, also known as counterfeiting and piracy. The paper then proposes a typology of different PPPs, as the term is used in very different ways in the literature. In the subsequent sections of the paper, empirical examples of global PPPs against IP crimes are analyzed, whose secretariats are hosted by three public international organizations: Interpol, the World Customs Organization (WCO), and the World Health Organization (WHO). By comparing the different paths of these three international organizations and their PPPs, five key factors are identified that influence the formation, maintenance, termination, and reform of such PPPs: (1) common ground, (2) absolute and/or relative gains of resources, (3) the management of the PPP and its discretion, (4) the representation of stakeholders, and (5) the policy pursued by the PPP.