Indaziflam {N‐[(1R,S)‐2,3‐dihyrdo‐2,6‐dimethyl‐1H‐inden‐1‐yl]‐6‐(1‐fluorethyl)1,3,5‐triazine‐2,4‐diamine} is a preemergence herbicide for annual weed control in turfgrass systems. Following indaziflam U.S. registration in 2010, sporadic cases of hybrid bermudagrass (HB) injury were reported. Field research was conducted from 2012 to 2014 evaluating indaziflam application rates [16 followed by 16 (28 d), 33, 49, or 65 g a.i. ha−1] and timings (fall‐only, fall‐plus‐spring, or spring‐only) in two environments (reduced sunlight [RS] and full sunlight [FS]) to elucidate their effect on HB growth. In Year 1, differences were not detected, while in Year 2 HB cover varied between environments. In Year 2, HB cover in the RS environment treated with 49 and 65 g ha−1 had 36 and 64% less visual cover 12 wk after initial spring treatment than the FS environment, respectively. Within the RS environment, indaziflam also reduced HB visual cover compared to the nontreated (77% cover). A bioassay study conducted with soil cores collected from field plots suggested HB cover reduction was minimally affected by indaziflam‐soil bioavailability, as perennial ryegrass biomass was not reduced beyond a 2.5‐cm depth. Weather conditions varied between years, with air temperatures ≤0°C occurring more frequently and to a greater magnitude in Year 2. The weather, coupled with reduced solar radiation in the RS environment may have contributed to HB cover reduction in Year 2. Overall, indaziflam applications to established HB in areas with suitable growth conditions were safe; however, unacceptable HB cover reductions were observed in areas with poor growth conditions. Indaziflam is safe on established bermudagrass grown in appropriate conditions. Bermudagrass‐indaziflam tolerance decreased when applied in a reduced sunlight setting. Severe winter climatic conditions exacerbated bermudagrass‐indaziflam injury.