Most fig ( Ficus carica ) cultivars have potentially two crops; fruit from the first crop are called brebas. This crop is commercially important in some Mediterranean area cultivars. The second or main crop, called figs, is the commercially important crop for most fig cultivars. Due to labor cost increases, harvest of the breba crop, with its low production and lower quality fruit, has become economically unviable in some cultivars. Unharvested brebas are potential sites for fungal pathogens and they attract insects. Spring ethephon applications of 250 to 500 ppm applied before full leaf expansion, when the largest fruit are about 1.5 to 2 cm in diameter reduced the breba crop load (≈92%) without adverse side effects. The use of early fall ethephon applications of 500 ppm also resulted in breba crop load reductions (≈30%), but with significantly lower efficacy than spring treatments. These fall and/or spring ethephon treatments did not affect the percentage of vegetative budbreak, breba weight, breba soluble solids concentration, fig crop load, fig weight, or ethephon residues. Thus, early spring ethephon application at 300 ppm (0.22–0.36 kg·ha −1 ), when breba fruit and leaves are just starting to develop and figs are not present, was a safe, effective and inexpensive way (about $16 per hectare) to reduce the breba crop. Currently, ethephon is included in the federal IR-4 program, and residue studies are ongoing as a protocol for future registration.