Abstract CO2 Sequestration has been proposed as a possible means of achieving sustainable development objectives and calls upon petroleum industry technology and expertise. Commercial application of long-term CO2 sequestration depends in large part on the ability to effectively model and verify the movement of injected gas. Software has been developed to both simulate CO2 migration and to predict seismic responses as a function of time. The co-simulation of fluid flow and reservoir geophysical parameters during the life of the reservoir provides useful information about the feasibility and optimal timing of 3D time-lapse (4D) seismic surveys. When CO2 sequestration is combined with EOR processes, the integrated flow model has the potential to help locate bypassed reserves, and to aid the reservoir characterization process by decreasing seismic processing time. The purpose of this paper is to demonstrate the applicability of the integrated flow model to CO2 sequestration. An example using a dome-structured aquifer illustrates the technology.