Abstract Asphaltenes are a very important component of reservoir fluids. They have a huge impact on crude oil viscosity and are a Flow Assurance concern. They can undergo a phase transition, giving rise to tar mats that seal aquifers precluding aquifer sweep. Local tar deposits can act as a drilling hazard. Upstructure tar (or bitumen) deposition can occur which can flow with produced light hydrocarbons greatly reducing the productivity index. In EOR, miscible gas injection can also give rise to asphaltene deposition. Characterizing these disparate observations is now performed within a simple overarching framework. Here, we combine asphaltene nanoscience, thermodynamics, and fluid mechanics to model asphaltene-rich fluid flow and asphaltene deposition that occur in reservoirs in geologic (or even production) time. This analysis successfully accounts for extensive measurements in several reservoirs in different stages of similar processes. Reservoir black oils with a late, light hydrocarbon charge experience asphaltene instability. This instability does not necessarily cause precipitation; instead, weak instability can cause a change in the nanocolloidal character of asphaltenes without precipitation. Consequently, this less stable asphaltene remains in the crude oil and is thus mobile. This process can result in fluid density inversions and gravity currents that pump asphaltene ‘clusters’ in oil over reservoir length scales relatively quickly in geologic time. These asphaltene clusters then establish very large asphaltene and viscosity gradients at the base of the reservoir. If the light hydrocarbon instability event continues, a regional tar mat can form. In contrast, if the light hydrocarbon charge is sufficiently rapid, the displacement of the contact between the original and new reservoir fluids overtakes and precipitates asphaltenes locally producing deposition upstructure often near the crest of the field. In this paper, several reservoirs are examined. Two reservoirs have massive, current gas charge and have bitumen deposition upstructure. Another reservoir is shown to be midway through a slower gas charge, with the asphaltene instability causing migration of asphaltenes from the top to the base of the oil column in the form of clusters creating large asphaltene gravity gradients. Another reservoir is shown to have this process completed yielding a 50 meter column of heavy oil at the base of the oil column underlain by a 10 meter regional tar mat. This integrated analysis enables a much simpler understanding of many production issues associated with asphaltenes and provides a way forward for treating disparate asphaltene problems within a single framework.