ABSTRACT The Guazuma ulmifolia Lamark (Malvaceae) is a non-endemic plant, popularly known as mutamba. Its leaves and roots are used in home remedies against dysentery and diarrhea, in the treatment of prostate, as a uterine stimulant and other diseases. Due to the characteristics presented and the growing interest in this species, a systematic review was carried out on the possible pharmacological and toxicological effects of Guazuma ulmifolia Lamark. As active compounds, the articles cited the presence of flavonoids, saponins, alkaloids, tannins, phenolic compounds and steroids in different parts of the plant and extracted with different solvents. Regarding the experimental studies, no articles were found with clinical test, and only 4 in vivo studies. About the pharmacological effects we can mention activity against leishmaniasis, hypoglycemic, anti-inflammatory, anticholinesterase, anti-obesity, antiseptic, cicatrizant and anthelmintic. The registered toxicological tests were directed against lineages of cancer cells, proving effective, however, there is a need for studies to attest the safety of G. ulmifolia use by the population. Therefore, it is imperative to carry out further studies to ensure the use of this plant, to know doses and form of indication, as well as clinical studies in order to guarantee a correct therapy. Keywords: Guazuma ulmifolia, toxicity, medicinal plants.