Chest pain is a common reason why patients seek medical consultation. Chest pain can be caused by life-threatening diseases and requires extensive diagnostic evaluation, especially to exclude acute cardiac pathologies. However, in the case of atypical chest pain with a normal electrocardiogram and serum levels of myocardial necrosis markers with in the reference ranges, non-cardiac causes of chest pain should be considered. This report describes the case of a 90-year-old female patient with recurrent chest pain who was eventually diagnosed with osteoporotic vertebral fractures of the thoracic spine.