Introduction: Tsegedea district is found in western Tigray region composed of 123,641 populations and 25 kebelles. The health facility coverage is 100 %( 5) for health centers and 93 %( 23) for health posts. Measles is an acute, highly contagious viral disease caused by measles virus.. As more countries immunize more children, measles deaths have been reduced by 71 per cent—from an estimated 548,000 in 2000 to 158,000 in 2011.However, according to the official report, an outbreak of measles is occurring throughout the regions of Ethiopia. Among these regions, Tigray region has reported 6 outbreaks of measles from, 2011-2013. We received 4 clinically suspected measles cases from 2 kebelles of the district from 6-10/2/2014. We investigated this cluster to confirm its etiology, describe its magnitude, identify potential risk factors and make recommendations. Methods: We investigated measles outbreak from 6-24/2/2014 in Tsegedea district by a casecontrol study. We recruited 20cases and 40controls by simple random sampling having a structured questionnaire. We entered the data to Epi-Info, version 7.6.1 and exported to SPSS, version 16 for analysis. We have computed the BMI, overcrowdings, vaccine efficacy (1-OR)*100 and herd immunity (from 2012-2014).