Extracellular microvesicles (EVs) released by different cells have been shown to facilitate the transfer of several pro-angiogenic as well as anti-antigenic factors that can regulate gene expression in endothelial cells. Our recent study has demonstrated that the profiles of cytokines and angiogenic-active factors in EVs are significantly changed in patients with diabetes that can act both pro-and anti-proliferative. We suggest that those factors may facilitate vascular regeneration and angiogenesis.