Dexketoprofen Trometamol is a NSAID, used as an analgesic and anti-inflammatory drug. It works by blocking the action of cyclo-oxygenase in the body. Conventional route of delivery has many drawbacks such as hepatic first-pass metabolism, reduced bioavailability, and fluctuating drug concentrations in the blood. These problems can be overcome by development of transdermal drug delivery system. The objective of this study was to develop and evaluate the transdermal patches of the drug Dexketoprofen Trometamol. The patches were prepared by solvent casting method using polymers; Ethyl cellulose, HPMC and ERS 100 in different ratios. The prepared formulations were uniform in their physical characteristics. The formulation F6, combination of polymer (HPMC: EC in ratio 4:1) showed maximum release of 85.77% in 24 hours. The resultant data was fitted in to zero, first, Higuchi and Peppas model. The results specify that Dexketoprofen Trometamol transdermal patch can be designed for obtaining better therapeutic benefits. Keywords: Transdermal drug delivery system, TDDS, Skin patches, Kinetics, NSAIDs, Analgesic, Invitro and exvivo drug release.