Corneal edema following contact with plant extracts occur not only with horticultural workers but also with amateur gardeners. The condition causes reasonable visual debility but is reversible and self limiting. Till date, no established therapeutic protocol exists for management of this particular condition.To re-examine the etiological factors behind this condition and to develop a definitive therapeutic prescript for this problem.Forty six patients suffering from this condition were randomly divided into two equal groups. Group A was treated with topical steroids (commercially available moxifloxacin 0.5% w/v + dexamethasone sodium phosphate 0.1% w/v), whereas Group B was treated with a placebo (carboxy methylcellulose 0.5% w/v). All patients were monitored on alternate days in terms of BCVA, non contact tonometry and slit lamp examination. Pachymetry was done on arrival and after complete resolution of corneal edema.In both the groups, corneal edema resolved in all eyes by the fifth day without any residual clinical deficit. The mean pachymetry value on presentation in Group A was 626 microns and in Group B was 628 microns, and returned to 550 microns or below by day five in all patients. Visual acuity was restored to 6/9 or better in all patients of Group B and 96% (n= 22) patients in Group A, but this deficiency was not related to the disease process in question.Botanical toxin induced corneal edema was self limiting and resolved in a time bound pattern without any sequel. Topical steroids neither seemed to hasten the resolution of corneal edema nor affected the final outcome of this clinical condition in any way.