Biological examination of fungicide efficacy based on tebuconazol (Orius 6FS) in recommended dose, in protection of Tilletia tritici (syn. Tilletia caries) were done since 2004 on winter wheat - KG-100 in localities "Se- lekciona stanica" (Inđija) and "Institut Tamis" (Pancevo). Experiments were done in wheat at standard method OEPP/EPPO, PP 1/19 (2) (1997). Phytotoxicity by PP (1/135(2). Intensity of infestation was calculated by method of Towsend-Heuberger, efficacy by Abbott, and statistical analyses by LSD and Duncan test. Infested wheat in control variant are 85.13% to 70.38% and efficacy of fungicides in variant with Orius 6FS and Raxil - T 515 FS are 100% for both of tested fungicides. Results with data of seed wheat germination pretreated with tested fungicides are 97.5-97.0 and control variant 95.5, immediately after sowing and after six months 98.5 (tested fungicides) to 96.5 (control variant). Yield are on variants with fungicides 7.6-8.6 and 11.6 compared with control variant 3.8 and 11.5. In winter wheat experiments, the infection of common bunt was high without affection the germination vigour of the seeds and on plants.