Apple cultivars were crossed according to the half-diallel and topcross mating design. Apple scab resistance of seedlings was estimated by using a 0-5 scale: 0 - no infection on leaves, 5 - more than 75% of leaf area infected. Percentage of scab resistant seedlings in crosses involving cultivars Prima varied from 35.8% to 67.6%, involving cultivars Florina and Arbat - 51.9-59.5% and 53.5-72.5%, respectively. Significant differences for resistance to scab were found among the crosses. Both general combining ability (GCA) and specific combining ability (SCA) were highly significant. The significance of GCA for scab resistance shows that genetic variability exists for this trait and selection should result in genetic progress, because the mean square for GCA was larger than that calculated for SCA. Therefore, selection of parents on its phenotype should be effective for development of resistant apple cultivars. The significant SCA estimates indicate that a large number of resistant seedlings from particular crosses should be selected.