The traditional curricula of medical schools have emphasized the acquisition of knowledge rather than its use, in t Paradoxically, great part of the advances of the medical practice have been driven by the advances in the basic (PBL) which rely on principles of cognitive psychology allow a better integration of the concepts of the basic scie approach the pedagogical model applied in the Medical School at "Universidade Estadual de Londrina" since 199 have been introduced , in specific the Metabolism block.