Hypohidrosis refers to diminished sweating in response to an appropriate thermal stimulus, leading to hyperthermia [1]. Different aetiologies of hypohidrosis include congenital absence of sweat glands, exogenous factors, dermatological disorders, neurological disorders, endocrine disorders, and Fabry disease [2-4]. Thermoregulatory sweating is regulated predominantly by the hypothalamus via the autonomic nervous system [5]. Here, we report the first case of a patient with pituitary-hypothalamic germinoma [...]