Effect of feeding dumpsite forage (Calapo -Calopogonium mucunoides) on the histology of the kidney and liver of rabbits (Oryctolagus cuniculus) was investigated. 24 rabbits; 20 females and 4 males were obtained and distributed randomly into two experimental groups of 10 females and 5 males with each of the groups being fed dumpsite forage and non-dumpsite forage respectively. The forage, specifically Calapo (Calopogonium mucunoides) was fed to the two groups’ ad-libitum with the nondumpsite fed group serving as the control. After a period of 20 weeks, the rabbits were sacrificed using chloroform soaked with cotton wool placed in the desiccators where the rabbit were place under anaesthesia. Kidney and Liver were harvested and fixed immediately in neutral buffered formalin, they were transported to the laboratory for histopathological analysis. The results revealed moderate areas of inflammation and hyperplasia in the liver of the dumpsite treated animals as compared to the non-dumpsite group which revealed normal cellular pattern with prominent hepatocytes, portal triad and sinusoidal lining with no abnormality being observed. For the kidney results, cellular abnormality with glomerular inflammation, tubular degeneration, degenerated epithelial lining and areas of inflammation were observed in the dumpsite treated groups as compared to the non-dumpsite which revealed normal cellular pattern for both the kidney and liver tissues. In conclusion, feeding of dumpsite forages to rabbits could pose hematoxic and cyto-architectural de-arrangement and pathological alterations with traces of cellular abnormality to the liver and kidney of rabbits, thus posing health risk in animal and human populations exposed to chemical substances from waste dumpsites.