New tools are critically needed to diversify weed control in many crops and to combat herbicide resistant weeds. PROteolysis-TArgeting Chimera (PROTAC) is a new molecular technique that consists of using an organic molecule designed to interact with a target protein and to recruit an E3 ligase. By bringing these two molecules together, PROTAC can trigger the action of the proteasome, a natural cellular mechanism, to degrade the protein of interest. PROTAC can potentially degrade enzymes, including those that are herbicide resistant, and structural proteins. Because of its potential to increase the number mechanisms and selectivity to interfere with plant metabolism, PROTAC should be explored as an innovative form of weed control for agricultural and non-agricultural systems.