The need to improve Education for Sustainable Development (ESD) provision in Greek secondary schools offers opportunities for innovation. This study shows results of applying a more integrated, collaborative and interactive approach, developed by using elements of the Impact of Materials on Society (IMOS) course. The modules and techniques selected for teacher training and classroom implementation are presented and responses from participants are summarised. Positive feedback from the two teacher training activities and two in-class sessions with students demonstrates the potential of this approach. The paper offers evidence that a systems approach to ESD is promising and worthy of further investigation.