Abstract. The research was conducted during 2019 - 2021 on pellic vertisol soil type. Under investigation was lentil cultivar Ilina (Lens culinaris Medik.). A total of 23 variants were investigated: untreated control, 8 herbicides – Pendistar 40 SC (pendimethalin), Dual gold 960 EC (S-metolachlor), Lentagran VP (pyridate), Challenge 600 SC (aclonifen), Zencor 600 SC (metribuzin), Wish top (quizalofop-P-ethyl), Zetrola (propaquizafop) and Passat 40 (imazamox), as well as combinations and tank mixtures between them. Soil-applied herbicides were used during the period after sowing before emergence. Foliar-applied herbicides were used during 2-3, 4-5 or 6-7 real leaf stage of the lentil. All of the herbicides, herbicide combinations and herbicide tank-mixtures were applied in a working solution of 300 l/ha. Mixing of foliar-applied herbicides was done in the tank on the sprayer. The combinations of herbicide Lentagran with soil-applied herbicides Pendistar and Dual gold, as well as herbicides Challenge with foliar-applied herbicides Wish top and Zetrola had an additive effect on herbicide efficacy. The herbicides Lentagran and Zencor, as well as their combinations, successfully controlled Clearfield and ExpressSun sunflower self-sown plants in lentil crops. The foliar-applied herbicide Passat controlled all annual and perennial broadleaved and graminaceous weeds and self-sown plants. The use of foliar-applied herbicide Passat and soil-applied herbicide Zencor at a dose of 900 g/ha led to high phytotoxicity in lentil plants – rate 3 according to the scale of EWRS. Double use of Zencor at doses of 600 + 300 g/ha and the combined use of the herbicides Challenge and Zetrola led to low phytotoxicity in lentil – rate 2 according to the scale of EWRS. The highest yields of lentil seeds were obtained by use of herbicide combinations Pendistar 5 l/ha + Lentagran 500 + 500 ml/ha and Pendistar 5 l/ha + Lentagran 1 l/ha. High yields were also obtained when combining Challenge 3 + 1 l/ha with Wish top 1.25 l/ha, as well as by the herbicide combination Challenge 4 l/ha + Wish top 1.25 l/ha.