It is believed that ALS inhibitor herbicides in combination with ACCase inhibitors can be used as an alternative to glyphosate in weed control in RR2/STS soybeans. In the present study, the efficacy of ALS inhibitor herbicides, in combination with haloxyfop, is evaluated in the control of weeds for post-emergence application (V4) of RR/STS soybeans. The experiment is carried out in the 2017/18 season in Piracicaba, São Paulo (SP), Brazil. The cultivar BMX Garra RR2/STS is used, and the treatments were composed by the application of ALS inhibitor herbicides in association with haloxyfop. The experimental design was a randomized block with four replications. Were evaluated control and dry mass of weeds, symptoms of injury in soybean plants and yield. The data were submitted to analysis of variance and the means of the treatments were compared by the Tukey test. Visual symptoms of injury were observed in soybean plants, mainly for the application of nicosulfuron and nicosulfuron + cloransulam. Soybean yield was higher in all herbicide treatments compared to the control without weeding. Associations between ALS inhibitor herbicides and haloxyfop applied post-emergence (V4) of soybean cultivar BMX Garra RR2/STS were effective in weed control.