The article highlights the results of the research carried out with the participation of the authors in May-December 2019 in the Dnipropetrovs’k regional institute for public administration, National academy for public administration under the President of Ukraine, at the request of the Dnipropetrovs’k Regional State Administration in the framework of the Dnipropetrovs’k region strategy - 2027 draft’s development.The main methodological principles that underlie the Dnipropetrovs’k region strategy’s development are characterized and the expediency of their implementation in the sphere of territories’ social and economic development is grounded.It was shown, that Dnipropetrovs’k region strategy’s development methodology envisages the application of a comprehensive integrative approach, which consists not only in mandatory observance of the latest normative documents in the field of regional development strategic planning, which provide for the strategy basic provisions’ formation on the basis of smart-specialization, but also in incorporating the results of modern reforms, in particular, in the field of decentralization, to the process of the regional development main problems’ identification and the strategic goals’ system formation.The methodology of region public administration bodies’ strategic activity is based on the problem-oriented approach and the concept of sustainable development, which presupposes keeping the balance of economic, social and environmental factors of development.It was substantiated that in order to ensure the strategy’s innovative orientation, it’s advisable to apply a cluster approach that facilitates the transition of the regional economy to an innovative development model and a qualitatively better investment environment in the region formation.The proposed methodology also envisaged the use of a problem-oriented approach together with SWOT analysis, which was carried out for the whole region across all spheres (branches) of the economic complex. This approach made it possible to select and adapt for each strategic objective the relevant aspects of SWOT analysis, on the basis of which specific problems that must be solved for the realization of this strategic goal were identified.Within the drafting of the Dnipropetrovs’k region development strategy 2027 the approach described in the article allowed for systematic formalization of actions, which should ensure a managed transition from the existing situation in the region to the desired and realistic possible state according to the formed strategic vision and its decomposition to the regional and local development programs and projects’ level.