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Biometrics & Biostatistics International Journal
Article . 2015 . Peer-reviewed
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Elastic Net Constrained Stereotype Logit Model for Ordered Categorical Data

Authors: André Aa, Williams; Kellie J, Archer;

Elastic Net Constrained Stereotype Logit Model for Ordered Categorical Data

Abstract

Gene expression studies are of growing importance in the field of medicine. In fact, sub-types within the same disease have been shown to have differing gene expression profiles. Often, researchers are interested in differentiating a disease by a categorical classification indicative of disease progression. For example, it may be of interest to identify genes that are associated with progression and to accurately predict the state of progression using gene expression data. One challenge when modeling microarray gene expression data is that there are more genes (variables) than there are observations. In addition, the genes usually demonstrate a complex variance-covariance structure. Therefore, modeling a categorical variable reflecting disease progression using gene expression data presents the need for methods capable of handling an ordinal outcome in the presence of a high dimensional covariate space. We present a method that combines the stereotype regression model with an elastic net penalty as a method capable of modeling an ordinal outcome for high-throughput genomic data sets. Results from the application of the proposed method to gene expression data are reported and the effectiveness of the proposed method is discussed.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
gold
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