The june issue of JERHRE features three themes: (1) Managing risks or unanticipated events that arise in research and pose serious ethical and practical questions. (2) Collaborating across cultures when relevant values are not shared, in particular values of individualism found largely in Western cultures versus community values which are more frequently found in traditional cultures. (3) Challenges to researchers and their mentors of learning and teaching how to responsibly resolve or ameliorate difficult ethical challenges.