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Organic Syntheses
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https://dx.doi.org/10.15227/or...
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Synthesis of 1,3-dimethyl-3-(p-tolyl)-1H-pyrrolo[3,2-c]pyridin-2(3H)-one by Cu(II)-Mediated Direct Oxidative Coupling

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2014 Switzerland Publisher:Organic SynthesesJournal:Organic Syntheses, volume 91, pages 221-232 (eissn: 2333-3553, Copyright policy )
Authors: Dey, Chandan; Kundig, Ernst Peter;

doi: 10.15227/orgsyn.091.0221

Synthesis of 1,3-dimethyl-3-(p-tolyl)-1H-pyrrolo[3,2-c]pyridin-2(3H)-one by Cu(II)-Mediated Direct Oxidative Coupling

Abstract

The CuCl2-mediated protocol was extended to the synthesis of 3,3-disubstituted aza-oxindoles. Compounds containing the aza-oxindole structural motif exhibit biological activities such as oral anti-inflammatory activity, and potent TrkA kinase and JAK 3 kinase inhibition. This article discusses the synthesis of 1,3-dimethyl-3-(p-tolyl)-1H-pyrrolo[3, 2-c]pyridine-2,(3H)-one by Cu(II)-mediated direct oxidative coupling. Keywords: N-Methyl-N-(pyridin-4-yl)-2-(p-tolyl)propanamide, 1,3-Dimethyl-3-(p-tolyl)-1H-pyrrolo[3,2-c]pyridin-2(3H)-one, CH coupling reaction, CuCl2 mediated aza-oxindole synthesis

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Switzerland
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Keywords

540, ddc: ddc:540

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
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bronze
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