Introduction: Job-burnout is a psychological expression for describing the experiment of negative attitude, morale and behavior when people face work-related stressors. It affects the physical, emotional and mental exhaustion, associate with suspicions about individuals’ competence and the value of their work. Methods: A total number of 40 librarians working in the libraries of Tabriz University of Medical Sciences, Iran, were chosen as the population of study. Two types of questionnaires were distributed among participants. First, the factors affecting the job-burnout; second the Maslach Burnout Inventory (MBI) for measuring the job-burnout scales among librarians. Results: The study showed that the highest frequencies of job-burnout dimensions among librarians were from the high level of emotional-exhaustion and depersonalization and low level of personal-performance and involvement. Conclusion: Analysis of data concluded that the university librarians believe, the low level of wages and benefits, the low status of librarians’ profession in the society, the deficiency of promotion and occupation advancement, and incorrect assessment of the librarians' job performance, has the most influence on the job-burnout among librarians.