Abstract Students usually have difficulties to understand abstract concepts of process control. Implementing in teaching process the inquiry-based learning helps students to follow methods and practices similar to those of professional scientists in order to construct knowledge. The paper describes the steps reached in simulation-based learning: from experimental data obtained by the students in their practical method (study and measurement of variables to some fermentation processes) to the simulated the behaviour of the process under a feedback control system. By providing opportunities for students to check their understanding and reflect on their learning process performance is enhanced over a traditional lecture course.