Accumulating evidence suggests that brain-adipose tissue bidirectional communications might be promising intervention point for cardiometabolic and neurodegenerative diseases (1). Alzheimer‘s disease (AD) is a progressive and yet incurable disorder characterized by memory loss and cognitive ability deterioration. It is the most common form of dementia, afflicting millions of humans globally. Although the progression of AD currently cannot be stopped or reversed, an increased understanding of its pathogenesis may give patients and their families chance for new therapies, which may at least delay the progress of the disease.