Pharmacokinetics and tissue residue of toltrazuril in broiler chickens
Copyright policy )Pharmacokinetics and tissue residue of toltrazuril in broiler chickens
<p>The pharmacokinetics and tissue residue of toltrazuril (Baycox<sup>®</sup>, Bayer Animal Health) were investigated in broiler chickens after repeated oral administrations of 7 mg/kg b.wt once daily for two consecutive days. Chickens were subjected to clinical diagnosis to ensure that each one is free from any Eimeria was received a standard broiler feed free from any medications. The results revealed that following repeated oral administration; toltrazuril peaked in blood with [C<sub>max</sub>] of 6.56 and 6.70 μg/ml at [T<sub>max</sub>] of 2.56 and 2.52 hours and the elimination half-life [t<sub>1/2β</sub>] of 14.92 and 16.19 hours and the mean residence times (MRT) were 21.33 and 23.14 hours after first and second doses, respectively. The tissue level concentrations were highest in the kidney and decreased in the following order: liver > lung > heart > muscle > skin and fat. No toltrazuril residues were detected in tissues and plasma after 8 days.</p>
- Cairo University Egypt
- Cairn University United States
- Cairo University
- Cairo University, Faculty of Veterinary Medicine Egypt
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