English holly (Ilex aquifolium), a commonly found ornamental evergreen, was first introduced to the Pacific Northwest in the 18th century. Characterized by its quick growth rate, it threatens native biodiversity and forest structure. Previous studies explored treatments for English holly removal, suggesting herbicide application by the Paint method as most effective in the short term. This current study assessed the long-term efficacy of the EZ-Ject and Paint methods in the Pacific Spirit Regional Park (PSRP) seven years post-treatment. Our results revealed no significant differences between the two treatments but an observable ability of the EZ-Ject method to achieve better herbicide efficacy over time and effectively suppress the regrowth of English holly sprouts, whereas the Paint method has rapid effectiveness. More intense use of EZ-Ject and further post-treatment monitoring are recommended to inhibit English holly regrowth effectively.