Terahertz time-domain spectroscopy and imaging of artificial RNA
Copyright policy )Terahertz time-domain spectroscopy and imaging of artificial RNA
We use terahertz time-domain spectroscopy (THz-TDS) to measure the far-infrared dielectric function of two artificial RNA single strands, composed of polyadenylic acid (poly-A) and polycytidylic acid (poly-C). We find a significant difference in the absorption between the two types of RNA strands, and we show that we can use this difference to record images of spot arrays of the RNA strands. Under controlled conditions it is possible to use the THz image to distinguish between the two RNA strands. We discuss the requirements to sample preparation imposed by the lack of sharp spectral features in the absorption spectra.
- University of Adelaide Australia
- Technische Universität Braunschweig Germany
- Technical University of Denmark Denmark
- University of Freiburg Germany
Medical and biological imaging, Medical optics and biotechnology, 535, far infrared, Spectroscopy
Medical and biological imaging, Medical optics and biotechnology, 535, far infrared, Spectroscopy
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