Homoclinic bifurcations in four-dimensional vector fields are investigated by setting up a local coordinate near a homoclinic orbit. This homoclinic orbit is principal but its stable and unstable foliations take inclination flip. The existence, nonexistence, and uniqueness of the 1-homoclinic orbit and 1-periodic orbit are studied. The existence of the two-fold 1-periodic orbit and three-fold 1-periodic orbit are also obtained. It is indicated that the number of periodic orbits bifurcated from this kind of homoclinic orbits depends heavily on the strength of the inclination flip.