Musculista senhousia (Benson in Cantor, 1842) is a soft sediment-dwelling mussel that has spread anthropogenically from its native Asia to North America, Australasia, and Europe. This byssal mat-forming species can becomeoverwhelmingly dominant and have dramatic impacts within invaded ecosystems, but its invasion may meet "ecological resistance" from native predators. In Mission Bay, San Diego, California, three fish species and two shorebirds were found to prey upon the mussel. Experimental results suggest that predation can dramatically impact intertidal mussel populations and may account for observed seasonal declines in the species. Despite the creation of a byssal cocoon, which may afford the mussel some protection, several taxa worldwide have been found to be Musculista predators. In addition, in areas where the mussel is native, humans impact mussel populations by gathering it for animal feed or bait, or to remove it from commercial shellfisheries grounds.