High blood pressure (HBP) is a public health problem with high prevalence and serious medical consequences. The objective of this study was to determine the prevalence of high blood pressure and its associated factors in adults aged 25 to 64 in the health district of Aplahoue in Benin. This was a cross-sectional study carried out in 2016. The study involved 540 participants randomly selected by cluster sampling techniques. A questionnaire was used to collect data on dietary patterns, lifestyles and socio-economic conditions. The multivariate logistic regression model was used to identify factors associated with HBP. The median age of participants was 40 years old with an interquartile range of [32-51.5] years. Mean systolic and diastolic blood pressure were 133.56 ± 20.68 and 83.26 ± 13.29 mmHg, respectively. The prevalence of HBP was 29.94%. The urban environment, the high frequency of salt consumption, the low frequency of fruit and vegetable consumption, the habit of smoking, physical inactivity, and being overweight were found to increase the risk of HBP. Interventions to promote healthy lifestyles are timely in the health district of Aplahoue.