Malaria disease is a pathology which occurs as a result of the oxidative stress. Three plants of the Ivorian pharmacopoeia are particularly used in the traditional medicine for the treatment of malaria in Cote d'Ivoire. They are Cochlospermum planchonii (Placo), Pericopsis laxiflora (Laper) and Harungana madagascariensis (Madhar).The objective of this study was to evaluate the in vitro antioxidant activity of the aqueous and methanolic extracts of three medicinal plants of Cote d'Ivoire. The quantitative measurement of total flavonoids gave the following results: Laper (560.80 mg QE/g ± 7.40), Madhar (352.50 mg QE/g ± 9.46) and Placo (314.20 mg QE/g ± 4.41). The total polyphenols were more concentrated in Laper (262.50 mg GAE/g ± 9.47) and Placo (203.20 mg GAE/g ± 2.21). Noticeable zinc content was found in Laper (13.56 ppm) and Placo (11.40 ppm) against 3.43 ppm in Madhar. The radical scavenging activity by 2,2-diphenyl-1-picryl hydrazyl (DPPH) and antiradical power measurement by ABTS (2,2' azino bis-3-ethylbenzothiazoline-6-sulphonic acid) assay have showed good activity for Laper (IC50 = 7.50 μg/mL) and placo (IC50 = 8.01 μg/mL). The standard antioxidant compound (quercetin) gave an IC50 = 4.00 μg/mL. This study suggested that the high content of total flavonoids, total phenols and minerals in these plants could partly justify the therapeutic use of at least two of the three plants.