This contribution describes opportunities and advantages related to the use of the “scenarios” approach in the design of resilient anthropic systems. A methodology that aims to support, from the early stages of the decision-making process, strategical choices concerning complex works and areas by duration, size and interactions with the environment. A model that, given the current situation of extreme economic and environmental uncertainty, could represent an effective collaboration protocol between decision makers, designers and experts of various disciplines, especially in the development of large-scale infrastructure systems and human settlements that involve extended planning and implementation timings, requiring a high degree of programmed adaptability.