Bovine respiratory disease (BRD) remains an important condition of calves that leads to reduced weight gain and productivity as well as incurring significant cost in terms of management, treatment and prevention. The disease is multi-factorial with numerous viruses (bovine herpesvirus 1 (BoHV1); bovine respiratory syncytial virus (BRSV); parainfluenza 3 virus (PI3); and bovine virus diarrhoea virus (BVDV)) and bacteria (Mycoplasma bovis, Pasteurella multocida, Mannheimia haemolytica, Histophilus somni) being implicated in its aetiology. While the economic impact is well documented, and despite in excess of 2900 research publications related to the disease in the last 30 years, BRD continues to be a major concern clinically.