Parkinson's is a complex degenerative disease which affects both motor and non-motor function and as such requires regular reassessment and collaboration between the patient and the healthcare team to achieve optimal outcomes. Complex medication regimes are often prescribed to manage symptoms; however, issues such as compliance, adherence and concordance need to be considered. The Parkinson's Nurse Specialist plays a central role in understanding patient needs and ability to manage medication regimes. The nurse has a fundamental function in achieving optimal medication adherence throughout the disease trajectory.