The concept of semiosphere coined by Lotman in analogy of Vernadsky’s biosphere can be considered as a starting point for the new model in the semiotics of culture that enables us to conceptualise the human culture in its great diversity, as well as a certain single system as a part of this diversity. Present article will clarify some points of dissonance between Lotman and Vernadsky, as well as consider the dual influence of Vernadsky and Prigogine on the workings of the semiosphere in relation to the cultural dynamics. As a conclusion, the article entertains the idea that if we take the comparison with Vernadsky a bit further, the concept of semiosphere could be reinvented rather as a main transformative force of the (human) environment.