Isoflavones and Rotenoids from the Leaves of Millettia brandisiana

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2008 English Publisher:Pharmaceutical Society of JapanJournal:Chemical and Pharmaceutical Bulletin, volume 56, pages 835-838 (issn: 0009-2363, eissn: 1347-5223,

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Authors: Pancharoen, Orasa; Athipornchai, Anan; Panthong, Ampai; Taylor, Walter Charles;

doi: 10.1248/cpb.56.835

pmid: 18520090

Isoflavones and Rotenoids from the Leaves of Millettia brandisiana

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Abstract

A new isoflavone, 4'-gamma,gamma-dimethylallyloxy-5,7,2',5'-tetramethoxyisoflavone, brandisianin A (1), was isolated from the leaves of Millettia brandisiana, along with one synthetically known isoflavone, 7,4'-di-O-prenylgenistein (2) and twelve known compounds. The structures were elucidated on the basis of extensive spectroscopic analysis. Two isolated compounds were tested for anti-inflammatory activity; 12a-hydroxy-alpha-toxicarol (11) showed significant anti-inflammatory activity.

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Keywords

Male, Spectrophotometry, Infrared, Anti-Inflammatory Agents, Non-Steroidal, Free Radical Scavengers, <i>Millettia brandisiana</i>, rotenoid, Isoflavones, Millettia, Rats, Plant Leaves, Rats, Sprague-Dawley, Rotenone, Animals, Edema, Indicators and Reagents, Spectrophotometry, Ultraviolet, Chromatography, Thin Layer, anti-inflammatory activity, isoflavone

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