$\DeclareMathOperator{\IntR}{Int{}^\text{R}}$Integer-valued rational functions are a natural generalization of integer-valued polynomials. Given a domain $D$, the collection of all integer-valued rational functions over $D$ forms a ring extension $\IntR(D)$ of $D$. For a valuation domain $V$, we characterize when $\IntR(V)$ is a Prüfer domain and when $\IntR(V)$ is a Bézout domain. We also extend the classification of when $\IntR(D)$ is a Prüfer domain.